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Studies demonstrate that NNMT inhibition "enhances fasting blood glucose levels, glucose tolerance, and insulin sensitivity" while reducing triglycerides and decreasing lipid deposition

Pinto JL, Abelln JM, Snchez FI: Incorporacin de las preferencias de los pacientes en la toma de decisiones clnicas

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Potential breaking of weight-loss plateaus, especially when standard diet/exercise alone have slowed

Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)