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Zhou Y et al (2018) Autocrine Mfge8 signaling prevents developmental exhaustion of the adult neural stem cell pool

The development of drugs targeting the CNS requires precise knowledge of their penetration into the brain 2 , and ideally, this information should be obtained as early as possible to avoid failure in late clinical development, when upward of $100 million is typically invested in a drug candidate

More serious risks to be aware of include: Pancreatitis: As with other GLP-1 receptor agonists, there is a theoretical and observed risk of acute pancreatitis

It has been the subject of over 130 peer-reviewed publications since the 1990s

drug toxicity (e.g