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Mounjaro does not directly cause B12 deficiency, but its appetite-suppressing effects may lead to reduced food intake and potentially suboptimal nutrient consumption over time

Vit B12 and synucleinopathy A recent study demonstrated that Vit B12 effectively impedes the formation of SN fibrils in a manner dependent on dosage in-vitro experiments

Meanwhile, the vitamin B component helps increase energy levels and may improve overall metabolic function, which can enhance calorie burning

Research shows that inadequate B12 levels may lead to: Anemia and weakness that limit physical activity Cognitive issues affecting motivation Mood changes that could impact adherence to weight loss programs [6] While initial findings are promising, with studies showing improved energy levels and metabolic function in patients using semaglutide with B12 [9] , more research is needed to understand the effects fully

In addition to reducing intake of the vitamin itself, bariatric surgery may diminish the secretion of intrinsic factor in the stomach, which is normally produced and released in response to food intake (Marcuard et al., 1989)