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DNA damage leads to inadequate DNA repair and mutations: DNA damage is typically repaired before replication, but when lesions persist or repair is faulty, as can occur via error-prone pathways like NHEJ, mutagenesis may ensue, contributing to carcinogenesis through the accumulation of alterations in key genes, as detailed in Section 3.3.1.2

10.24875/RIC.18002575 Rev Invest Clin

10.1083/jcb.137.4.813 141 SarrafS

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However, results across studies vary, and larger trials are necessary to confirm these preliminary findings