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To ascertain the role of oxidative stress in senescence induction, cells were incubated with ascorbate (vitamin C) or Trolox (vitamin E derivative), two well-characterized antioxidants, which are water or lipid soluble respectively

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Insofar as GAD autoantibodies are detected early in nearly all T1D, the logical segue was that islets would be depleted of the product of this enzyme, namely, GABA