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2024 May 8;46:101078

Zanirati G, et al

Prior studies have reported that the deletion of the IDH2 gene, one of the isoforms of isocitrate dehydrogenase, in ischemia-reperfusion injury (IRI) and cisplatin-induced acute kidney injury results in decreased NADPH levels, reduced GPX activity, and mitochondrial dysfunction in renal tubular cells [15,16,17]