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The ECM of untreated tumors is thought to be a hard microenvironment, whereas a soft ECM enhances drug resistance by increasing NF-B signaling activity and downregulating pro-apoptotic JNK signaling activity

This includes D-penicillamine (distributed under the brand named including Cuprimine, a capsule, and Depen, a tablet), which was the first oral therapy developed for Wilson disease

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Category-wise Analysis Therapy Type Insights Cell therapy is set to continue to dominate the regenerative therapies market with an approximate 45.0% share in 2025, driven by its widespread clinical use, particularly in oncology and musculoskeletal disorder treatments