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Initial Metabolic Changes (Days 1-14): While cellular-level metabolic changes begin within hours of the first AOD-9604 administration, noticeable subjective effects typically emerge within the first one to two weeks

Response: With respect to the comments that our proposals would create distortions in the MS-DRG relative weights, we note that there is some similarity between these comments and the comments that we received during the FY 2021 rulemaking (85 FR 58883)

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Montreal: 1951

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