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Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy

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The NP formulation of LS, GSH, and their combination caused a significant decrease in rats compared to the usual forms of these compounds (Fig

P-glycoprotein (P-gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P-gp status of active pharmaceutical ingredients (APIs) intended for human use

Finally, clinical translation is impeded by the lack of disease-specific profiles of lipid metabolism and antioxidant system dysregulation