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J Pharmacol Exp Ther 311, 677682

PLoS ONE 7 , e30178 (2012)

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Studies have included patients ranging from young adults to those over 75 years, with no clinically relevant age-related differences in pharmacokinetics

Most promisingly, we could successfully soak in and solve crystal structures with the NMR hit 27 and several of its analogues to fully characterise the binding modes within this fragment hit series