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Pregnancy and breastfeeding status should be disclosed, as B12 is generally safe but individual circumstances require clinical judgment

Also, it stimulates fibroblasts to produce more Growth Hormone Receptors (GHR), which improves collagen synthesis, speeds up tissue remodeling, and diminishes the production of non-functional fibrotic scar tissue

The vitamin B 12 supplementation study in pregnancy from South India 24 and the study from Bangladesh 26 used very high doses of 20100 RDA with no reported adverse effects

Multiple conserved sites have been identified in the GH receptor binding domain, which are highly conserved across different species, indicating their important functional significance in the evolutionary process