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1a, b, Additional file 1: Fig

Quercetin undergoes the first-pass effect, i.e., quercetin is metabolized in the liver once it is entered into our body due to its poor absorption in the gastrointestinal tract since it is surrounded by a mucus layer with 90% water content, and it undergoes the first-pass effect (gastrointestinal instability) (Date et al., 2011