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Moreover, while the drafting of this paper was underway, a 10-week, randomized, placebo-controlled, double-blind trial to evaluate the effect of NMN supplementation on metabolic function in 25 postmenopausal women with prediabetes was reported 21 , in which NMN supplementation increased muscle insulin sensitivity, insulin signaling, and remodeling in women with prediabetes who are overweight or obese 21

Thus, TMPRSS2 does not regulate Gip transcription in vivo

Its effects are dose-dependent: low concentrations (520 M) enhance antioxidant capacity (e.g., 20 M curcumin increased SOD activity by 47% in RAW264.7 cells) (Lin et al., 2019)

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