hemoglobin glutathione Erythrocyte metabolic pathways synopsis. 2,3 DPG, Suggested α-tocopherol mechanism on hemolysis

However, trials using B-vitamins to reduce this risk have sometimes failed to improve outcomes, including heart attacks and death from heart disease

Some compounds like milk thistle have shown promise for liver support in certain circumstances, but results are mixed in clinical studies

I think in Europe, probably in Latin America, they do a better job because they use these tools that are available to them

Succinic Semialdehyde Dehydrogenase Deficiency: Lessons from Mice and Men

This has been attributed to increased mechanical fragility (iron deficient RBC are more rigid and more likely to fragment as they traverse through small capillaries under high shear), however oxidative injury to red blood cells is likely contributing to keratocyte formation (Yoo et al 2009) (given that antioxidant enzymes in red blood cells, such as glutathione peroxidase, contain iron)