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De novo protein design is a powerful approach for elucidating the principles of protein folding and function, enabling the generation of receptors, enzymes, and ion channels from scratch 31,82

Cell-cycle synchronization was performed as follows: cells were synchronized at the G1/S boundary using a double-thymidine (2 mM, Sigma) block

Late-Stage Minimal Labeling of Peptides and Proteins for Real-Time Imaging of Cellular Trafficking

(4) Warnings and Precautions Neutropenia: Monitor complete blood count prior to start of IBRANCE therapy and at the beginning of each cycle, as well as on Day 15 of the first 2 cycles, and as clinically indicated

Tumor cells take up a large amount of glutamine to meet their rapid proliferation requirements, which is supported by the upregulation of glutamine transporters