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Some symptoms that may indicate a more serious underlying condition include: Severe, sudden onset of pain Pain accompanied by fever or chills Neurological symptoms such as weakness, numbness, or vision changes In addition to these red flags, other concerning signs may include persistent vomiting, difficulty swallowing, or changes in mental status, such as confusion or difficulty concentrating

Hsieh MJ, Lee CH, Chueh HY, Chang GJ, Huang HY, Lin Y, et al

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