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Limitations across studies include reliance on rodent models and short-term outcomes, limited cell-specific genetics and safety data, frequent use of bulk LC3-II/p62 without rigorous flux assays, and focus on single pathways despite crosstalk between mTOR/AMPK, ubiquitination, and mitophagy

To confirm Andexxas clinical benefit AstraZeneca used data from the Phase IV ANNEXA-I study, which found that the drug could induce significantly better hemostasis in patients with acute intracranial bleeding than usual care

This ratio did not change in the semaglutide group [10]

This review focuses on the pathogenic role of S100 proteins in psoriasis

HMDB 4.0: the human metabolome database for 2018