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A simple rotation schedule cycling through 6-8 different sites provides adequate recovery time for each location between uses

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Softer substrates promote chondrogenesis in MSCs and NP progenitor cells, upregulating aggrecan, Sox9, and collagen II expression (Olivares-Navarrete et al., 2017

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The TIL therapy carries a boxed warning for treatment-related mortality, prolonged severe cytopenia, severe infection, and cardiopulmonary and renal impairment