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Falagas ME et al., Crit Care

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Further findings (102) reveal that iron overload leads to the increase of MMP and the accumulation of lipid peroxide by affecting GSH and fatty acid cycle, which further promotes the activation of osteoclasts and apoptosis of osteoblasts, leading to increased bone resorption and decreased bone formation

These neuropathic symptoms can sometimes be misinterpreted as joint pain, particularly when affecting the hands, wrists, knees, or ankles