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This includes: Direct evidence: directly measured experimental support that blocking or preventing a KE prevents or impacts downstream KEs in the pathway in the expected fashion

PHYSIOLOGY OF ACTH RELEASE Pulsatility of ACTH Release Frequent sampling of ACTH with deconvolution analysis reveals that it is secreted in pulses from the corticotroph with 40 pulses 1.5 measured per 24 hours, on analysis of 10-minute sampling data

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The authors have also proposed an equilibrium-based model to characterize drug-surfactant interactions in pH-controlled systems, reflecting both interactions and interdependence among all drug-containing species: unionized drug in water, ionized drug in water, unionized drug in micelles, and ionized drug in micelles

Stress-induced changes of methylglyoxal level and glyoxalase I activity in pumpkin seedlings and cDNA cloning of glyoxalase Igene