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Description

MLKL drives basal resistance to ferroptosis by depleting PUFAs, whereas ACSL4 promotes basal resistance to necroptosis by making the membrane less susceptible to MLKL-driven permeabilization [16, 214]

J Biol Chem 2015;290:2312434

Abils J, Prez de la Cruz A, Castao J, Rodrguez Elvira M, Aguayo E, Moreno-Torres R y cols

To characterize the interactions between the selected RDPA protein BRD4 and PIP2, we performed pull-down experiments using PIP2-conjugated beads to mimic naturally occurring PIP2 structures under different conditions