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PARK2 mutant mice present with pathological behavior disrupted glucose metabolism and pathological gene expression in the midbrain PD patients with PARK2 mutations have upregulated -oxidation and dysregulated glucose metabolism 14,15

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Liver health: The liver is responsible for numerous vital functions, including detoxification, metabolism, and synthesis of essential compounds

The up-regulation of the striatal dopamine transporters activity by cAMP is PKA-, CaMK II- and phosphatase-dependent