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J Epidemiol 27(9):447450 Newman NJ (2005) Hereditary optic neuropathies: from the mitochondria to the optic nerve

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However, under oxidative stress, Bach1 dissociates from the HO-1 promoter, and stress signals induce the dissociation of Nrf2 from Kelch-like ECH-associated protein 1 (Keap1), which then binds to AREs and initiates the downstream expression of oxidative stress-resistant HO-1 to prevent ROS-induced cellular damage and maintain the organisms antioxidant response (Zhang et al., 2019)

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In the realm of skin disease treatment, the regulatory role of FSP1 could emerge as a potential target for addressing inflammatory skin conditions such as psoriasis and venous ulcers ( 2.9 AMPK AMPK plays a pivotal role in regulating ferroptosis as the primary sensor of cellular metabolic status and energy levels ( In-depth research has revealed that the activation of AMPK is regulated by its upstream kinase liver kinase B1 (LKB1), a significant tumor suppressor, particularly in malignant tumors such as lung cancer, where mutations in LKB1 are common ( When cells encounter ferroptosis-inducing factors, the activation of AMPK not only inhibits the activity of its downstream acetyl-CoA carboxylase 1 (ACC1) but also reduces the synthesis of fatty acids ( During the process of skin ferroptosis, the role of AMPK is particularly important