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Evodiamine has antitumor activity in many kinds of tumors, such as lung tumor, gastric tumor, colorectal tumor and ovarian tumor (201204)

There are many documented clinical cases, all of them varied, with a multitude of symptoms, combinations of several of them, and uncertain onset, and with relatively good responses to treatment, but sometimes with very serious consequences if action is delayed: pancytopenia, organ failure, partial or permanent vision loss that is not recovered, heart attacks, and death

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The ratio between GSH and GSSG is commonly used to measure the cellular OS using commercial assays and high-performance liquid chromatography [Chatuphonprasert et al ., 2019]