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4a), which catabolizes GSH to yield 5-oxoproline and cysteinylglycine (Cys-Gly) 42

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In contrast, ALA exerts its principal effects on mitochondrial metabolism through its established role as an essential cofactor for mitochondrial -ketoacid dehydrogenase complexes, including pyruvate dehydrogenase and -ketoglutarate dehydrogenase, thereby facilitating efficient entry of glycolytic substrates into the tricarboxylic acid cycle and sustaining electron transport chain activity under oxidative stress conditions

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J., & Shi, W