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Twenty-four WT and twenty-four RAMP1/3 KO male mice were fed a 60% HFD for 18 weeks followed by a 45% HFD for six weeks

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2014 Phase II trial (117 bowel surgery patients, NCT00672074), ipamorelin given as 0.03 mg/kg IV twice daily for up to 7 days produced treatment-related adverse event rates similar to placebo

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Because the prescription follows the data, dose titration is built into the model