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Initial signs may include vomiting, diarrhea, with or without blood, anorexia, and lethargy

Given this situation, renal replacement therapies should aim to offer treatment that is not only aimed at prolonging survival, but rather at improving quality of life

In clinical settings, especially intensive care, lactate is quantified via LDH-catalyzed reactions, producing NADH, which is measurable by spectrophotometry at 340 nm and correlates with plasma lactate levels