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Unfortunately once chronic inflammation becomes entrenched and mitochondria oxidatively stressed (less CYP27B1) exogenous 1,25(OH) 2 D3 is needed (Warren et al., 2021)

Science 364 , eaau6323 (2019)

Studies have shown that low doses of AA can promote ferroptosis and enhance the anti-tumor immune effects induced by immune checkpoint blockade (ICB) therapy (145)