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The term substituted as used herein, refers to all permissible substituents of the compounds described herein

As a non-limiting example, the tumor a malignant tumor called Hodgkin lymphoma located in lymphoid tissue

They're three different molecules doing three different things

Hypoxia, DNA repair and genetic instability

Chimeric Antigen Receptors (CARs): As used herein, the term chimeric antigen receptor or CAR refers to an artificial chimeric protein comprising at least one antigen specific targeting region (ASTR), a transmembrane domain and an intracellular signaling domain, wherein the antigen specific targeting region comprises a full-length antibody or a fragment thereof