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Abbreviations CDKs: Cyclin-dependent kinases CDK5: Cyclin-dependent kinase-5 GSTP1: Glutathione S-transferase P1 EMT: Epithelial Mesenchymal Transition MTC: Medullary thyroid carcinoma ADD1: Adducin1 PPAR: Peroxisome proliferator-activated receptor PCa: Prostate cancer PDX: Patient-derived xenograft PDAC: Pancreatic ductal adenocarcinoma Ral GEFs: Ral guanine nucleotide-exchange factors EZH2: Enhancer of zeste homolog GBM: Glioblastoma PIKE: A-Phosphatidylinositol 3 kinase enhancer-A CRMP2: Collapsin response mediator protein 2 ACSS2: Acetyl-CoA synthetase 2 OGT: O-GlcNAc transferase DYRK1A: Dual-specificity tyrosine phosphorylation-regulated kinase 1 A HCC: Hepatocellular carcinoma PRMT1: Protein arginine methyltransferase 1 SCLCs: Small cell lung cancer NSCLCs: Non-small cell lung cancer LUAD: Lung adenocarcinoma hASH1: Achaete-scute homolog-1 CAP1: Adenylate cyclase associated protein 1 PD: L1-Programmed cell death ligand 1 IFN: Interferon HNSCC: Head and neck squamous cell carcinoma MM: Multiple myeloma EphA4: Eph receptor A4 ATM: Ataxia Telangiectasia Mutated DLC: 1-Deleted in Liver Cancer 1 FAK: Focal adhesion kinase PIPKI90: Phosphatidylinositol 4-phosphate 5-kinase type I 90 ERK: Extracellular signal-regulated kinase TRIM59: Tripartite motif-containing 59 RPA32: Replication protein A ESRP1: Epithelial Splicing Regulatory Protein 1 DRP1: Dynamin-related protein 1 TIGAR: TP53 induced-glycolysis regulatory phosphatase CK2: Casein kinase 2 mPTP: Mitochondrial permeability transition pore AR: Androgen receptor TNBC: Triple-negative breast cancer STAT: Signal transducer and activator of transcription References Songyang Z, Lu KP, Kwon YT, Tsai LH, Filhol O, Cochet C, et al

Most robust data comes from small trials in specific populations with documented oxidative stress or chronic conditions

Under the influence of ferrous ions or lipoxygenases, the overexpressed unsaturated fatty acids on the cell membrane undergo lipid peroxidation, thereby inducing cell death

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