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Magkos F, Fraterrigo G, Yoshino J, Luecking C, Kirbach K, Kelly SC, et al

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European Food Safety Authority (EFSA)

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CPT1A and metabolic diseases Patients with metabolic syndrome, obesity, and type 2 diabetes frequently have non-alcoholic fatty liver disease, hypertriglyceridemia, and other lipid metabolism abnormalities, which can be somewhat improved by increasing CPT1A expression ( CPT1A in vascular diseases Metabolism of endothelial cell depends on FAO to resist oxidative stress in the development of blood vessels, and CPT1A plays a crucial role in this process, offering a new potential target for the treatment of vascular-related diseases ( CPT1A in heart failure Heart failure is one of the top causes of death and disability around the world, but there is yet no safe and effective clinical therapy for heart failure ( Perhexiline was an effective anti-angina drug used in the last century, but was recalled by the manufacturer because of hepatotoxicity and peripheral neurotoxicity ( CPT1A in NAFLD The global obesity epidemic has dramatically increased the prevalence of non-alcoholic fatty liver disease (NAFLD), with no approved treatment now (Weber et al., 2020)