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Smaller nanoparticles (1100 nm) can interact with plasma membranes and penetrate and pass through the cell membrane via phagocytosis, endocytosis, or micropinocytosis [48]

Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-v3 interactions

Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, Cruz De Los Santos M, Anfossi S, Shimizu M, Shah MY, Ling H, Shen P, Multani AS, Pardini B, Burks JK, Katayama H, Reineke LC, Huo L, Syed M, Song S, Ferracin M, Oki E, Fromm B, Ivan C, Bhuvaneshwar K, Gusev Y, Mimori K, Menter D, Sen S, Matsuyama T, Uetake H, Vasilescu C, Kopetz S , Parker-Thornburg J, Taguchi A, Hanash SM, Girnita L, Slaby O, Goel A, Varani G, Gagea M, Li C, Ajani JA, Calin GA

But here's a spoiler alert: everyone is different and no one approach fits all