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Zinc rescues obesity-induced cardiac hypertrophy via stimulating metallothionein to suppress oxidative stress-activated BCL10/CARD9/p38 MAPK pathway

Similarly, the upregulation of ZnT5 serves to restore zinc levels in cellular secretory pathways, particularly in the Golgi apparatus, where luminal zinc is loaded onto secreted proteins that require zinc for their catalytic activity (254)

Ponrartana S, Aggabao PC, Hu HH, Aldrovandi GM, Wren TA, Gilsanz V

Viral infections activate types I and III interferon genes through a common mechanism

Despite this progress, the exact roles of MTH1 in diseases and tumors, as well as the therapeutic efficacy of these inhibitors, remain incompletely understood