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Genetically predicted circulating homocysteine, vitamin B12, and folate levels and risk of multiple sclerosis: evidence from a two-sample Mendelian randomization analysis

77 ERK signaling has also been found to be greatly linked to calcium channels to cause abnormal synaptic functions, chromatin remodeling, and ion channel activity

Each mechanism of dysfunction at the pre-synaptic, post-synaptic, and peri-synaptic level offers itself as a target for intervention to improve stabilization, junctional signaling, and synapse integrity [213], potentially even before symptomatic weakness in those with genetic susceptibilities