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Am J Hematol 97(7):885-894, 2022

GSH synthetase (GSS) is an enzyme that catalyzes the second step in synthesis of GSH

Additionally, the authors acknowledge the general positive bias of the published results, the lack of replicative validation studies, and the resulting risk of overestimating treatment efficacy in preclinical models that would provide confidence for the current findings and improve translational significance

Carnitine octanoyltransferase (CrOT) is predominantly found in peroxisomes and plays a key role in the transfer of medium-chain acyl groups from the peroxisomes to the cytoplasm and mitochondria for further degradation [27]

Wu J, Liu S, Liu G, Dombkowski A, Abrams J, Martin-Trevino R et al