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Moreover, most natural products interact with multiple protein targets, exerting intricate biological effects in vivo (Wang Z

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[13] [15] Post-marketing use of azelaic acid has been associated with the development of hypersensitivity reactions (including angioedema, ocular inflammation, facial swelling, and urticaria) and asthma exacerbation (i.e., dyspnea, wheezing)

[DOI] [PubMed] [Google Scholar] Liu L.X., Zhang Y.Y., Liu T., Ke C.R., Huang J.Z., Fu Y.J., et al

Interleukin 13 receptor alpha 2 (IL13R2): Expression, signaling pathways and therapeutic applications in cancer