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Dupilumab, an IL-4R monoclonal antibody, demonstrates the clinical impact of IL-4R-triggered pathways in severe Th2-high asthma [53, 54]

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Biochimica et Biophysica Acta, 1792 (10), 931940

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Notably, semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist originally developed for T2DM and obesity, has shown robust efficacy in achieving resolution of steatohepatitis, underscoring its potential for repurposing in MASLD management [94]

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This involves the free thiol cysteamine, which can deplete approximately 95% of the lysosomal cystine content

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Berger JS, Roncaglioni MC, Avanzini F: Aspirin for the primary prevention of cardiovascular events in women and men

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