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Degeneration of the lower motor neurons in the brainstem and spinal cord and the upper motor neurons in the motor cortex results in gradual denervation of voluntary muscles, leading to disruption of neural networks through a complex set of mechanisms eventually culminating in motor and non-motor symptoms (Table 2

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an irritability subscale of the Aberrant Behavior Checklist (ABC)(Norris et al., 2019)) improved significantly following increased levels of cysteine (a GSH precursor), leading to an increased GSH plasma concentration(Hardan et al., 2012)

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Composed of three amino acidsglutamine, glycine, and cysteineglutathione is fundamental for energy production, immune function, and cellular repair