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The -secretase enzymes are generally believed to reside at the plasma membrane, although some studies have suggested that a pool of -secretase may also exist at the trans -Golgi network (TGN) (Sisodia, 1992

Heredity 83: 637643

c , Representative bright field images of Huh7 and H1299 cells from vehicle and combo treatment (SU056: 1 M, BAY876: 1 M) groups with or without 2DG (5 mM) treatment (72 h)

Transport across the BBB may be facilitated by sodium-dependent transport system [76] or converting cysteine to cystine, which is subsequently exchanged with intracellular glutamate via the cystine-glutamate antiporter, and reduced back to cysteine for GSH production [115, 116]