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The discrepancy between this study and the data herein may reflect the heterogeneous nature of CD and disease severity between the patient donors (the current study used monocytes from individuals with mild-to-moderate CD), the mechanisms of action of the various pro-death stimuli, or differences in apoptotic versus non-apoptotic death in macrophages

doi: 10.1152/physrev.00045.2009 215 SerinoM.Blasco-BaqueV.NicolasS.BurcelinR

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Cagrilintide acts via amylin and calcitonin receptors, while semaglutide, tirzepatide, and retatrutide target incretin (GLP-1/GIP) receptors