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In cultured primary cells, Mn suppressed astrocytic glutamate handling and downregulated the expression of related genes 272

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In conclusion, the above experiments confirm the identification of four distinct chloroacetamide chemotypes with broad senolytic activity

Nevertheless, significant heterogeneity exists among studies regarding the precise roles of inflammatory pathways and the efficacy of targeted interventions, indicating that IBD subtypes must be molecularly stratified to avoid a one-size-fits-all therapeutic approach

Moya et al