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Product glucuronides are exported from hepatocytes by MRP2 (canalicular, into bile) and MRP3/MRP4 (basolateral, into blood for renal excretion)

discard if cloudy or particulate Dosing Calculation Example: If reconstituting 5 mg with 2.5 mL bacteriostatic water, the concentration is 2 mg/mL (2000 mcg/mL)

Jacobson T, Maki K, Orringer C, Jones P, Kris-Etherton P, Sikand G, Forge R, Daniels S, Wilson D, Morris P, Wild R, Grundy S, Daviglus M, Ferdinand K, Vijay K, Deedwania P, Aberg J, Liao K, McKenney J, Ross J, Braun L, Ito M, Bolick J, Dicklin M, Kirkpatrick C, Rhodes K, Smith N, Blackett P, DeFerranti S, Gidding S, Davey R-E, McCrindle B, McNeal C, Urbina E, Dayspring T, Underberg J, Lopez J, Pirzada A, Roderguez C, Fichtenbaum C, Gallant J, Horberg M, Longenecker C, Myerson M, Overton E, Coblyn J, Curtis J, Plutzky J, Solomon D, Bays H, Brown W

Y.ZhengR.ChenC.ChenY.LiuQ.et al (2017)

Indicatively, an initial cycle of 3-4 weekly infusions is recommended for NAD+ and a cycle of 4-6 total infusions for glutathione, followed by a maintenance phase