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Brainstem serotonin and norepinephrine producing nuclei (dorsal raphe nucleus and locus coeruleus, respectively) are vulnerable to cell loss, tau deposition and -synuclein pathology early in normal aging, AD and PD [59, 60, 61] This early involvement of brainstem nuclei is thought to contribute to the high prevalence of depression, anxiety, and sleep disturbance, preceding cognitive decline and motor symptom onset [61,62,63,64,65]

But right now, PRP and BMAC remain the most effective, real-world tools for improving joint health because they: improve ligament stability strengthen tendons calm harmful inflammation improve synovial fluid quality support cartilage health decrease meniscus degeneration Cartilage is important, but joint health is much more than cartilage thickness

Anesthesiology 96 , 10531061 (2002)

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