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In addition to the above, some natural medicines have been proved to have anti-RA activity ( Table 1 ): polyphenols including curcumin, chlorogenic acid and punicalagen, flavonoids including hesperidin, 7,3-dimethoxyhesperidin, kaempferol and genistein, terpenes including pentaacetyl geniposide, gentiopicrin and betulinic acid, glycosides including emodin, and cyanidin-3-O-glucuronide, alkaloids including berberine and matrine, -mangiferin (a xanthone derivative of mangosteen pericarp), cinnamaldehyde (an aldehyde active compound Chinese medicine herb Cinnamomum cassia), thymoquinone (the main component of the volatile oil in Nigella sativa L.), periplocin (one of the main active components in Periploca sepium Bunge)

Parenti, G., Medina, D

Physiological jump in erythrocyte redox potential during Plasmodium falciparum development occurs independent of the sickle cell trait

There was also a prolonged but little increase in internal p25 level, which was associated with improved learning and memory (Noh and Seo, 2014)

That "lessons from one tissue applied to another" idea is a big part of why the compound is so intriguing to people who treat injuries for a living