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MOTS-c# Evidence Level: Preclinical | FDA Status: Category 2

*Correspondence: Pedro Grandes, [email protected] These authors have contributed equally to this work and share last authorship This article was submitted to Nutrition, Psychology and Brain Health, a section of the journal Frontiers in Nutrition Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

64 SileikyteJ.Blachly-DysonE.SewellR.CarpiA.MenaboR.Di LisaF.et al (2014)

This has been reported as a major resistance mechanism against cDDP in several types of cancer [64, 65] and is believed to justify cell death when repairs are not possible [66]

This is accomplished with inhibition of the serotonin transporter protein or sensitization of serotonin receptors or inhibits MA, alterations in the transmission of GABAergic and/or glutamatergic transmitters, increase BDNF, effect on concentrations of serotonin in the synaptic cleft and act on dopamine