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In this context, Du et al., noted loss of tissue resident macrophages in colon biopsies from patients with ulcerative colitis, that was accompanied by decreased superoxide dismutase 2 expression (an important antioxidant) in the macrophages [3]

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Possible causes of hypermethioninemia Hypermethioninemia (plasma concentration of Met above 45M) (27) could be induced by a number of causes such as high Met diet, dysregulation of Met metabolism, or genetic causes including MATI/MATIII deficiency, CBS deficiency, and GNMT deficiency (28)