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Z tego wzgldu zwizek ten pozostaje istotnym narzdziem badawczym w analizach nad komrkowym starzeniem, replikacyjn ywotnoci komrek oraz molekularnymi markerami zwizanymi z wiekiem

Indeed, enhancing lysosomal-mediated proteolysis by overexpressing transcription factor EB (TFEB) in neuromelanin-producing rats was shown to reduce the intracellular neuromelanin density, attenuate PD-like inclusion formation, prevent nigrostriatal neurodegeneration, and reverse motor impairment [18]

However, from a biochemical and pharmacological perspective, it makes sense to associate these disturbances with a decreased activity of mitochondrial function

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