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The importance of BBB integrity and vascular remodeling in neurodegeneration is supported by evidence highlighting their role in disease progression (Sweeney et al

In patients with vasospastic angina (n = 22, age 4164), L-citrulline supplementation (0.8 g/d, 48 weeks) increases brachial artery flow-mediated dilation, plasma NOx levels, and L-arginine/ADMA ratio (Morita et al., 2013)

CIRBP, Cold-inducible RNA-binding protein

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TECs, central to both injury sensing and myofibroblast generation (197), initiate fibrogenic signaling, while myofibroblasts execute matrix accumulation (198)