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This adaptation allows them to tolerate massive oxidative loads that would trigger apoptosis in non-malignant cells, effectively creating a privileged redox state that immune cells lack

The key to the diverse roles of different classes of GSTs is due to their structure, specifically the composition and spatial localization of amino acid residues composed in the enzymatic active sites

Mitchell KG, Parra ER, Nelson DB, Vaporciyan AA, Hofstetter WL, Mehran RJ, Swisher SG, Rice DC, Sepesi B, Walsh GL, Zhang J, Behrens C, Kalhor N, Weissferdt A, Moran CA, Wistuba II, Fujimoto J, Roth JA, Antonoff MB

Controversies exist over the TP53 mutation status dependencies of APR-246

The Chara Genome: Secondary Complexity and Implications for Plant Terrestrialization