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For best penetration, apply to slightly damp skin or layer with a humectant like hyaluronic acid

The IGF-1 MSIA-SRM provides a linear dynamic range spanning 11,500 ng/mL ( Figure 3 ), enabling a single assay to quantify IGF-1 over its biologically relevant concentrations and the ability to quantify as little as 5 femtomoles of IGF-1 from 40 mL human plasma

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Studies show that the transcription factor FOXO4 plays a protective role in senescent cells by maintaining the protein p53 in a sequestrated state within nuclear structures, thereby inhibiting its ability to initiate apoptosis